/* ===========================================================
   IPMG Research · Neural Epic Edition
   Dark / synapse-glow / editorial
   =========================================================== */

:root {
  /* palette — synapse glow */
  --bg-0: #05040a;
  --bg-1: #0a0714;
  --bg-2: #120a22;
  --bg-3: #1a0f30;
  --ink-0: #f5ecff;
  --ink-1: #d8cbf0;
  --ink-2: #9c8bc4;
  --ink-3: #6a5d8a;
  --line: rgba(167, 139, 250, 0.14);
  --line-strong: rgba(167, 139, 250, 0.32);

  /* accents */
  --magenta: #ec4899;
  --magenta-soft: #f472b6;
  --cyan: #06e0ff;
  --cyan-soft: #67e8f9;
  --violet: #a78bfa;
  --violet-soft: #c4b5fd;
  --amber: #fbbf24;

  /* semantic */
  --accent: var(--magenta);
  --accent-2: var(--cyan);
  --accent-3: var(--violet);

  /* density (tweakable) */
  --density: 1;
  --gap-sm: calc(8px * var(--density));
  --gap-md: calc(16px * var(--density));
  --gap-lg: calc(32px * var(--density));
  --gap-xl: calc(64px * var(--density));
  --pad-card: calc(24px * var(--density));

  /* type */
  --font-sans: 'Inter Tight', 'Inter', system-ui, sans-serif;
  --font-mono: 'JetBrains Mono', 'IBM Plex Mono', ui-monospace, monospace;
  --font-display: 'Fraunces', 'Times New Roman', serif;
  --dyslexic-font: 'Inter Tight';

  color-scheme: dark;
}

/* Accent themes (tweakable) */
[data-accent="synapse"] {
  --accent: #ec4899;
  --accent-2: #06e0ff;
  --accent-3: #a78bfa;
}
[data-accent="aurora"] {
  --accent: #34d399;
  --accent-2: #22d3ee;
  --accent-3: #818cf8;
}
[data-accent="plasma"] {
  --accent: #fb923c;
  --accent-2: #f472b6;
  --accent-3: #c084fc;
}
[data-accent="deepsea"] {
  --accent: #22d3ee;
  --accent-2: #3b82f6;
  --accent-3: #a78bfa;
}

[data-density="compact"] { --density: 0.75; }
[data-density="comfortable"] { --density: 1; }
[data-density="spacious"] { --density: 1.35; }

[data-motion="off"] *,
[data-motion="off"] *::before,
[data-motion="off"] *::after {
  animation: none !important;
  transition: none !important;
}
[data-motion="reduced"] * {
  animation-duration: 0.3s !important;
  transition-duration: 0.2s !important;
}

/* reset */
* { box-sizing: border-box; }
html, body {
  margin: 0;
  background: var(--bg-0);
  color: var(--ink-0);
  font-family: var(--font-sans);
  font-feature-settings: "ss01", "cv11";
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
  overflow-x: hidden;
}
body {
  min-height: 100vh;
  background:
    radial-gradient(1200px 700px at 85% -10%, rgba(236, 72, 153, 0.14), transparent 60%),
    radial-gradient(1000px 600px at -10% 40%, rgba(6, 224, 255, 0.10), transparent 60%),
    radial-gradient(800px 500px at 50% 110%, rgba(167, 139, 250, 0.12), transparent 60%),
    var(--bg-0);
}
img, svg { display: block; max-width: 100%; }
a { color: inherit; text-decoration: none; }
button { font: inherit; color: inherit; background: none; border: 0; cursor: pointer; }

:focus-visible {
  outline: 2px solid var(--accent-2);
  outline-offset: 3px;
  border-radius: 4px;
}
::selection { background: var(--accent); color: #fff; }

h1, h2, h3, h4 {
  margin: 0;
  font-family: var(--font-display);
  font-weight: 400;
  letter-spacing: -0.02em;
  line-height: 1.02;
}
h1 { font-size: clamp(44px, 6vw, 88px); }
h2 { font-size: clamp(32px, 4vw, 56px); }
h3 { font-size: clamp(22px, 2.4vw, 32px); }
p  { margin: 0; line-height: 1.6; color: var(--ink-1); }

.mono { font-family: var(--font-mono); font-feature-settings: "ss01"; letter-spacing: -0.01em; }
.serif { font-family: var(--font-display); }
.tiny { font-size: 11px; letter-spacing: 0.22em; text-transform: uppercase; }

/* layout primitives */
.container {
  width: 100%;
  max-width: 1400px;
  margin: 0 auto;
  padding: 0 clamp(20px, 4vw, 48px);
}
.section {
  padding: clamp(48px, 8vw, 120px) 0;
  position: relative;
}
.grid { display: grid; gap: var(--gap-md); }
.stack { display: flex; flex-direction: column; gap: var(--gap-md); }
.row { display: flex; align-items: center; gap: var(--gap-sm); }
.row-between { display: flex; align-items: center; justify-content: space-between; gap: var(--gap-md); }

/* chips */
.chip {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  padding: 5px 10px;
  border: 1px solid var(--line-strong);
  border-radius: 999px;
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--ink-1);
  background: rgba(255,255,255,0.02);
  white-space: nowrap;
}
.chip .dot {
  width: 6px; height: 6px; border-radius: 50%;
  background: var(--accent-2);
  box-shadow: 0 0 10px var(--accent-2);
}
.chip.live .dot { background: #22c55e; box-shadow: 0 0 10px #22c55e; animation: pulse 1.8s ease-in-out infinite; }
.chip.phase-2 .dot { background: var(--amber); box-shadow: 0 0 10px var(--amber); }
.chip.phase-3 .dot { background: var(--accent); box-shadow: 0 0 10px var(--accent); }
.chip.phase-4 .dot { background: var(--accent-3); box-shadow: 0 0 10px var(--accent-3); }

@keyframes pulse {
  0%, 100% { opacity: 1; transform: scale(1); }
  50% { opacity: 0.5; transform: scale(1.4); }
}
@keyframes bold-pulse {
  0%, 100% { opacity: 0.85; r: 4.5; }
  50%      { opacity: 1;    r: 6.2; }
}
@keyframes core-breathe {
  0%, 100% { opacity: 0.75; }
  50%      { opacity: 1; }
}
@keyframes filament-drift {
  0%, 100% { opacity: 0.6; }
  50%      { opacity: 0.95; }
}
.brain-filaments { animation: filament-drift 4s ease-in-out infinite; }

/* card surface */
.card {
  position: relative;
  background: linear-gradient(180deg, rgba(255,255,255,0.025), rgba(255,255,255,0.005));
  border: 1px solid var(--line);
  border-radius: 16px;
  padding: var(--pad-card);
  transition: border-color 0.3s, transform 0.3s, background 0.3s;
  overflow: hidden;
}
.card:hover {
  border-color: var(--line-strong);
}
.card-glow::before {
  content: "";
  position: absolute; inset: -1px;
  border-radius: 16px;
  padding: 1px;
  background: linear-gradient(135deg, var(--accent), transparent 40%, var(--accent-2));
  -webkit-mask: linear-gradient(#000 0 0) content-box, linear-gradient(#000 0 0);
  mask: linear-gradient(#000 0 0) content-box, linear-gradient(#000 0 0);
  -webkit-mask-composite: xor;
  mask-composite: exclude;
  opacity: 0;
  transition: opacity 0.4s;
  pointer-events: none;
}
.card-glow:hover::before { opacity: 1; }

/* buttons */
.btn {
  display: inline-flex;
  align-items: center;
  gap: 10px;
  padding: 14px 22px;
  border-radius: 999px;
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: 0.14em;
  text-transform: uppercase;
  border: 1px solid var(--line-strong);
  color: var(--ink-0);
  background: rgba(255,255,255,0.03);
  transition: all 0.3s;
  cursor: pointer;
}
.btn:hover { background: rgba(255,255,255,0.08); border-color: var(--accent-2); transform: translateY(-1px); }
.btn-primary {
  background: linear-gradient(135deg, var(--accent), var(--accent-3));
  border-color: transparent;
  color: #fff;
  box-shadow: 0 10px 30px -10px var(--accent);
}
.btn-primary:hover { box-shadow: 0 14px 40px -10px var(--accent); }
.btn-ghost { background: transparent; border-color: var(--line); }

/* arrow */
.arrow { transition: transform 0.3s; }
.btn:hover .arrow { transform: translateX(3px); }

/* link */
.link {
  color: var(--accent-2);
  border-bottom: 1px dotted var(--line-strong);
  transition: color 0.2s;
}
.link:hover { color: var(--accent); }

/* eyebrow */
.eyebrow {
  display: inline-flex;
  align-items: center;
  gap: 10px;
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.28em;
  text-transform: uppercase;
  color: var(--ink-2);
}
.eyebrow::before {
  content: "";
  width: 24px; height: 1px;
  background: var(--accent-2);
}

/* progress bar */
.progress-track {
  position: fixed;
  top: 0; left: 0; right: 0;
  height: 2px;
  background: transparent;
  z-index: 100;
  pointer-events: none;
}
.progress-fill {
  height: 100%;
  background: linear-gradient(90deg, var(--accent), var(--accent-2), var(--accent-3));
  width: var(--progress, 0%);
  transition: width 0.1s linear;
}

/* nav */
.nav {
  position: sticky;
  top: 0;
  z-index: 50;
  backdrop-filter: blur(14px) saturate(140%);
  background: rgba(5, 4, 10, 0.72);
  border-bottom: 1px solid var(--line);
}
.nav-inner {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 16px clamp(20px, 4vw, 48px);
  gap: 24px;
}
.brand {
  display: flex; align-items: center; gap: 10px;
  font-family: var(--font-mono);
  font-size: 13px;
  letter-spacing: 0.08em;
}
.brand-mark {
  width: 28px; height: 28px;
  display: grid; place-items: center;
}
.nav-links {
  display: flex; gap: 4px;
  flex-wrap: wrap;
}
.nav-link {
  padding: 8px 14px;
  border-radius: 999px;
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: 0.1em;
  color: var(--ink-2);
  transition: all 0.2s;
}
.nav-link:hover { color: var(--ink-0); background: rgba(255,255,255,0.04); }
.nav-link.active {
  color: var(--ink-0);
  background: rgba(236, 72, 153, 0.12);
  border: 1px solid var(--line-strong);
}
@media (max-width: 900px) {
  .nav-links { display: none; }
}

/* footer */
.footer {
  border-top: 1px solid var(--line);
  padding: 60px 0 40px;
  margin-top: 80px;
}
.footer-inner {
  display: grid;
  grid-template-columns: 2fr 1fr 1fr 1fr;
  gap: 40px;
}
@media (max-width: 800px) {
  .footer-inner { grid-template-columns: 1fr 1fr; }
}
.footer h4 {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.2em;
  text-transform: uppercase;
  color: var(--ink-2);
  margin-bottom: 14px;
}
.footer a {
  display: block;
  color: var(--ink-1);
  font-size: 14px;
  padding: 4px 0;
  transition: color 0.2s;
}
.footer a:hover { color: var(--accent-2); }

/* read time */
.read-time {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.15em;
  color: var(--ink-3);
  text-transform: uppercase;
  display: inline-flex;
  align-items: center;
  gap: 6px;
}

/* utility */
.grad-text {
  background: linear-gradient(135deg, var(--accent), var(--accent-2) 60%, var(--accent-3));
  -webkit-background-clip: text;
  background-clip: text;
  -webkit-text-fill-color: transparent;
}
.signal-text {
  color: var(--accent-2);
  text-shadow: 0 0 20px rgba(6, 224, 255, 0.4);
}
.magenta { color: var(--magenta); }
.cyan { color: var(--cyan); }
.violet { color: var(--violet); }
.muted { color: var(--ink-2); }
.dim { color: var(--ink-3); }

/* bg decorations */
.grain {
  position: fixed;
  inset: 0;
  pointer-events: none;
  opacity: 0.04;
  mix-blend-mode: overlay;
  z-index: 1;
  background-image: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' width='160' height='160'><filter id='n'><feTurbulence baseFrequency='0.9' numOctaves='2' stitchTiles='stitch'/></filter><rect width='100%' height='100%' filter='url(%23n)'/></svg>");
}

.scan-line {
  height: 1px;
  background: linear-gradient(90deg, transparent, var(--accent-2), transparent);
  opacity: 0.4;
}

/* scroll-reveal */
.reveal {
  opacity: 0;
  transform: translateY(24px);
  transition: opacity 0.8s ease-out, transform 0.8s ease-out;
}
.reveal.in {
  opacity: 1;
  transform: translateY(0);
}

/* focus-mode (distraction free) */
body[data-focus="on"] .nav,
body[data-focus="on"] .footer,
body[data-focus="on"] .tweaks-panel-wrap,
body[data-focus="on"] .focus-hide { display: none !important; }
body[data-focus="on"] .focus-dim { opacity: 0.2; pointer-events: none; }
body[data-focus="on"] .focus-toggle-inline { display: inline-flex !important; }

/* neuro visuals toggle */
body[data-neuro="off"] .neuro { display: none !important; }

/* ========================================================
   BRAIN DIAGRAM — anatomical medical-illustration styling
   ======================================================== */
.brain-diagram {
  background: linear-gradient(180deg, rgba(15, 10, 28, 0.5), rgba(8, 5, 16, 0.7));
  border: 1px solid var(--line);
  border-radius: 20px;
  padding: 24px 28px 28px;
  position: relative;
}
.brain-diagram::before {
  content: "";
  position: absolute;
  inset: 0;
  border-radius: 20px;
  background-image:
    linear-gradient(rgba(167,139,250,0.04) 1px, transparent 1px),
    linear-gradient(90deg, rgba(167,139,250,0.04) 1px, transparent 1px);
  background-size: 40px 40px;
  pointer-events: none;
  mask-image: radial-gradient(ellipse at center, black 40%, transparent 100%);
}
.brain-diagram > * { position: relative; z-index: 1; }

.brain-header {
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  padding-bottom: 14px;
  margin-bottom: 6px;
  border-bottom: 1px solid var(--line);
}
.brain-meta-kicker {
  font-size: 9px;
  letter-spacing: 0.25em;
  color: var(--accent-2);
  margin-bottom: 6px;
}
.brain-header-left { flex: 1; min-width: 0; }
.brain-meta-title {
  font-size: 15px;
  font-weight: 500;
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
  color: var(--ink-0);
  letter-spacing: 0.01em;
}
.brain-view-toggle {
  display: flex;
  gap: 2px;
  border: 1px solid var(--line-strong);
  border-radius: 999px;
  padding: 3px;
  background: rgba(0,0,0,0.3);
}
.brain-view-toggle button {
  background: transparent;
  border: 0;
  color: var(--ink-3);
  font-family: inherit;
  font-size: 9px;
  letter-spacing: 0.2em;
  padding: 6px 12px;
  border-radius: 999px;
  cursor: pointer;
  transition: all 0.2s;
}
.brain-view-toggle button:hover { color: var(--ink-1); }
.brain-view-toggle button.active {
  background: var(--accent);
  color: #fff;
}

.brain-stage-wrap {
  position: relative;
  width: 100%;
  margin-top: 14px;
  padding: 72px 80px 72px; /* room for leader labels outside the image */
}
.brain-stage {
  position: relative;
  width: 100%;
  border-radius: 14px;
  overflow: hidden;
  background: #000;
  box-shadow: 0 20px 60px rgba(0,0,0,0.55), inset 0 0 0 1px rgba(255,255,255,0.04);
}
.brain-base-img {
  position: absolute;
  inset: 0;
  width: 100%;
  height: 100%;
  object-fit: cover;
  user-select: none;
  -webkit-user-drag: none;
  filter: contrast(1.02) saturate(1.05);
}
.brain-vignette {
  position: absolute;
  inset: 0;
  pointer-events: none;
  background:
    radial-gradient(ellipse at center, transparent 55%, rgba(6,4,14,0.55) 100%),
    linear-gradient(180deg, rgba(6,4,14,0.0) 70%, rgba(6,4,14,0.35) 100%);
  mix-blend-mode: multiply;
}
.brain-overlay-svg {
  position: absolute;
  left: 80px;
  right: 80px;
  top: 72px;
  width: calc(100% - 160px);
  height: auto;
  overflow: visible;
}
@media (max-width: 720px) {
  .brain-stage-wrap { padding: 54px 10px 60px; }
  .brain-overlay-svg { left: 10px; right: 10px; top: 54px; width: calc(100% - 20px); }
}

.brain-label-txt {
  font-family: var(--font-sans);
  font-size: 10.5px;
  letter-spacing: 0.01em;
}
.brain-label-short {
  font-family: var(--font-mono), ui-monospace, monospace;
  font-size: 10px;
  letter-spacing: 0.22em;
  font-weight: 600;
}
.brain-label-full {
  font-family: var(--font-sans);
  font-size: 11px;
  letter-spacing: 0.01em;
}

.brain-info {
  margin-top: 18px;
  padding: 14px 18px;
  min-height: 62px;
  background: rgba(0,0,0,0.35);
  border: 1px solid var(--line);
  border-radius: 12px;
  transition: border-color 0.2s, background 0.2s;
}
.brain-info.visible {
  border-color: var(--accent);
  background: linear-gradient(90deg, rgba(236,72,153,0.08), rgba(0,0,0,0.35));
}
.brain-info-head {
  display: flex;
  align-items: baseline;
  gap: 14px;
  margin-bottom: 4px;
}
.brain-info-kicker {
  font-size: 9px;
  letter-spacing: 0.25em;
  color: var(--accent-2);
}
.brain-info-title {
  font-size: 16px;
  font-weight: 500;
  color: var(--ink-0);
}
.brain-info-fn {
  font-size: 13px;
  color: var(--ink-2);
  line-height: 1.5;
}
.brain-info-conditions {
  margin-top: 8px;
  font-size: 9px;
  letter-spacing: 0.22em;
  color: var(--ink-3);
}
.brain-info-hint {
  font-size: 12px;
  color: var(--ink-3);
  text-align: center;
  padding-top: 6px;
}
.brain-info-hint .mono {
  color: var(--accent-2);
  font-size: 10px;
  letter-spacing: 0.18em;
  padding: 2px 6px;
  border: 1px solid var(--line-strong);
  border-radius: 4px;
}

@media (max-width: 680px) {
  .brain-header { flex-direction: column; gap: 10px; }
  .brain-label-full { display: none; }
  .brain-label-short { font-size: 10px; }
}

/* Tweaks panel */
.tweaks-panel-wrap {
  position: fixed;
  right: 20px;
  bottom: 20px;
  z-index: 90;
  display: none;
}
body[data-tweaks="on"] .tweaks-panel-wrap { display: block; }
.tweaks-panel {
  width: 320px;
  background: rgba(10, 7, 20, 0.92);
  backdrop-filter: blur(20px);
  border: 1px solid var(--line-strong);
  border-radius: 18px;
  padding: 20px;
  box-shadow: 0 20px 60px rgba(0, 0, 0, 0.6);
  max-height: 80vh;
  overflow-y: auto;
}
.tweaks-panel h3 {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: 0.2em;
  text-transform: uppercase;
  color: var(--ink-0);
  margin-bottom: 16px;
  display: flex;
  justify-content: space-between;
  align-items: center;
}
.tweaks-group { margin-bottom: 18px; }
.tweaks-label {
  display: block;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 0.15em;
  text-transform: uppercase;
  color: var(--ink-2);
  margin-bottom: 8px;
}
.tweaks-options { display: flex; gap: 6px; flex-wrap: wrap; }
.tweaks-opt {
  padding: 8px 12px;
  border-radius: 8px;
  border: 1px solid var(--line);
  font-family: var(--font-mono);
  font-size: 11px;
  color: var(--ink-1);
  cursor: pointer;
  transition: all 0.2s;
}
.tweaks-opt:hover { border-color: var(--line-strong); }
.tweaks-opt.active {
  background: var(--accent);
  border-color: var(--accent);
  color: #fff;
}
.swatch {
  width: 28px; height: 28px; border-radius: 8px;
  padding: 0;
  cursor: pointer;
  border: 2px solid transparent;
  transition: all 0.2s;
}
.swatch.active { border-color: var(--ink-0); }


/* ===========================================================
   CLINICAL TRIAL ALERT — 9-section NP briefing
   =========================================================== */

.trial-alert {
  --ta-accent: var(--accent);
  position: relative;
}

/* ---------- rail ---------- */
.ta-rail {
  position: fixed;
  left: 24px;
  top: 50%;
  transform: translateY(-50%);
  z-index: 40;
  display: flex;
  flex-direction: column;
  align-items: flex-start;
  gap: 10px;
  pointer-events: auto;
}
.ta-rail-count {
  font-size: 10px;
  letter-spacing: 0.2em;
  color: var(--ink-2);
  margin-bottom: 6px;
  padding-left: 4px;
}
.ta-rail-dots {
  display: flex;
  flex-direction: column;
  gap: 4px;
  background: rgba(5,4,10,0.72);
  border: 1px solid var(--line);
  padding: 10px 10px;
  border-radius: 14px;
  backdrop-filter: blur(14px);
}
.ta-rail-dot {
  position: relative;
  display: flex;
  align-items: center;
  gap: 10px;
  background: transparent;
  border: 0;
  padding: 6px 0;
  cursor: pointer;
  color: var(--ink-3);
  width: 100%;
}
.ta-rail-line {
  display: block;
  width: 18px;
  height: 2px;
  background: var(--ink-3);
  border-radius: 2px;
  transition: all .25s;
  flex-shrink: 0;
}
.ta-rail-label {
  font-size: 9px;
  letter-spacing: 0.18em;
  opacity: 0;
  transform: translateX(-6px);
  transition: all .2s;
  color: var(--ink-2);
}
.ta-rail-dot:hover .ta-rail-label { opacity: 1; transform: translateX(0); }
.ta-rail-dot:hover .ta-rail-line { background: var(--ink-1); width: 26px; }
.ta-rail-dot.active .ta-rail-line {
  background: var(--ta-accent);
  width: 36px;
  box-shadow: 0 0 12px var(--ta-accent);
}
.ta-rail-dot.active .ta-rail-label { opacity: 1; transform: translateX(0); color: var(--ink-0); }

@media (max-width: 1100px) { .ta-rail { display: none; } }

/* ---------- section shell ---------- */
.ta-section {
  position: relative;
  min-height: 100vh;
  padding: 80px 0;
  display: flex;
  align-items: center;
  border-bottom: 1px solid var(--line);
  overflow: hidden;
}
.ta-section:last-of-type { border-bottom: 0; }
.ta-bg-glow {
  position: absolute;
  inset: 0;
  pointer-events: none;
  opacity: 0.9;
  z-index: 0;
}
.ta-inner {
  position: relative;
  z-index: 2;
  width: min(1100px, 92vw);
  margin: 0 auto;
  padding: 0 24px;
}
.ta-inner-wide {
  width: min(1320px, 94vw);
}
.ta-center { text-align: center; }
.ta-center .ta-actions, .ta-center .ta-meta { justify-content: center; }

.ta-pageno {
  position: absolute;
  bottom: 32px; left: 50%; transform: translateX(-50%);
  font-size: 10px;
  letter-spacing: 0.3em;
  color: var(--ink-3);
  padding: 6px 12px;
  border: 1px solid var(--line);
  border-radius: 999px;
  background: rgba(5,4,10,0.6);
}

.ta-eyebrow {
  font-size: 11px;
  letter-spacing: 0.3em;
  color: var(--ta-accent);
  margin-bottom: 18px;
  text-transform: uppercase;
}
.ta-back {
  display: inline-block;
  font-size: 11px;
  letter-spacing: 0.2em;
  color: var(--ink-3);
  margin-bottom: 40px;
  text-transform: uppercase;
}
.ta-back:hover { color: var(--ink-0); }

.ta-h2 {
  font-family: var(--font-display);
  font-size: clamp(36px, 5vw, 68px);
  line-height: 1.04;
  letter-spacing: -0.02em;
  margin-bottom: 24px;
}
.ta-h2.ta-big { font-size: clamp(44px, 6vw, 86px); }
.ta-big2 {
  font-family: var(--font-display);
  font-size: clamp(48px, 7vw, 104px);
  line-height: 0.98;
  letter-spacing: -0.02em;
}

.ta-lede {
  font-size: clamp(18px, 1.6vw, 22px);
  color: var(--ink-1);
  max-width: 720px;
  line-height: 1.55;
  margin-top: 16px;
}
.ta-lede em { font-family: var(--font-display); font-style: italic; color: var(--ink-0); }
.ta-small { font-size: 14px; margin-top: 24px; }
.ta-footnote { font-size: 13px; }

/* ---------- S1 ---------- */
.ta-s1 { min-height: 100vh; }
.ta-s1 .ta-hero {
  font-family: var(--font-display);
  font-size: clamp(88px, 16vw, 220px);
  line-height: 0.9;
  letter-spacing: -0.04em;
  margin: 24px 0 16px;
  background: linear-gradient(180deg, var(--ink-0) 30%, var(--ta-accent) 110%);
  -webkit-background-clip: text;
  background-clip: text;
  -webkit-text-fill-color: transparent;
  filter: drop-shadow(0 0 40px color-mix(in oklab, var(--ta-accent) 40%, transparent));
}
.ta-tagline {
  font-size: clamp(18px, 2vw, 26px);
  color: var(--ink-1);
  max-width: 680px;
  margin: 0 auto;
  line-height: 1.4;
}
.ta-sig {
  margin-top: 32px;
  font-family: var(--font-display);
  font-style: italic;
  font-size: clamp(22px, 2.4vw, 30px);
  color: var(--ink-0);
}
.ta-meta {
  display: flex;
  gap: 12px;
  margin: 32px 0 24px;
  font-size: 11px;
  letter-spacing: 0.18em;
  color: var(--ink-2);
  flex-wrap: wrap;
}
.ta-meta-dot { color: var(--ta-accent); }
.ta-actions {
  display: flex;
  gap: 14px;
  flex-wrap: wrap;
  margin-top: 16px;
}

/* ---------- S2 ---------- */
.ta-callout {
  display: flex;
  gap: 20px;
  margin-top: 40px;
  padding: 24px 28px;
  border: 1px solid var(--line);
  border-radius: 14px;
  background: rgba(255,255,255,0.02);
}
.ta-callout-line {
  width: 3px;
  flex-shrink: 0;
  border-radius: 3px;
  background: var(--ta-accent);
}
.ta-callout-kicker {
  font-size: 11px;
  letter-spacing: 0.25em;
  color: var(--ta-accent);
  margin-bottom: 8px;
}
.ta-callout-body {
  font-size: 17px;
  color: var(--ink-1);
  line-height: 1.5;
}
.ta-callout-strong {
  border-width: 2px;
  padding: 20px 24px;
  margin-top: 36px;
  align-items: center;
  background: linear-gradient(135deg, color-mix(in oklab, var(--ta-accent) 12%, transparent), transparent);
  font-size: 22px;
}
.ta-callout-hand { font-size: 28px; flex-shrink: 0; }

/* ---------- S3 glance ---------- */
.ta-glance {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 20px;
  margin-top: 40px;
}
.ta-glance-cell {
  padding: 32px 24px;
  border: 1px solid var(--line);
  border-radius: 16px;
  background: linear-gradient(180deg, rgba(255,255,255,0.03), rgba(255,255,255,0.005));
  position: relative;
}
.ta-glance-cell::before {
  content: "";
  position: absolute;
  inset: 0;
  border-radius: 16px;
  padding: 1px;
  background: linear-gradient(180deg, color-mix(in oklab, var(--ta-accent) 35%, transparent), transparent 40%);
  -webkit-mask: linear-gradient(#000 0 0) content-box, linear-gradient(#000 0 0);
  mask: linear-gradient(#000 0 0) content-box, linear-gradient(#000 0 0);
  -webkit-mask-composite: xor;
  mask-composite: exclude;
  pointer-events: none;
}
.ta-glance-num {
  font-family: var(--font-display);
  font-size: clamp(44px, 5vw, 72px);
  line-height: 1;
  letter-spacing: -0.02em;
  margin-bottom: 10px;
}
.ta-glance-label {
  font-size: 11px;
  letter-spacing: 0.2em;
  color: var(--ink-0);
  text-transform: uppercase;
  margin-bottom: 6px;
}
.ta-glance-sub { font-size: 12px; color: var(--ink-2); line-height: 1.4; }
.ta-glance-footer {
  margin-top: 32px;
  font-size: 12px;
  color: var(--ink-2);
  letter-spacing: 0.1em;
  padding-top: 20px;
  border-top: 1px solid var(--line);
}
@media (max-width: 900px) {
  .ta-glance { grid-template-columns: repeat(2, 1fr); }
}

/* ---------- S4 differentiator ---------- */
.ta-diff {
  display: grid;
  grid-template-columns: 1fr auto 1fr;
  gap: 24px;
  align-items: stretch;
  margin-top: 40px;
}
.ta-diff-old, .ta-diff-new {
  padding: 28px;
  border: 1px solid var(--line);
  border-radius: 14px;
  position: relative;
}
.ta-diff-old { opacity: 0.7; }
.ta-diff-new { border-width: 2px; background: linear-gradient(135deg, rgba(255,255,255,0.03), transparent); }
.ta-diff-kicker {
  font-size: 10px;
  letter-spacing: 0.25em;
  color: var(--ink-2);
  margin-bottom: 12px;
}
.ta-diff-text { font-size: 20px; line-height: 1.35; color: var(--ink-1); }
.ta-diff-text.strong { color: var(--ink-0); font-weight: 500; }
.ta-diff-why { font-size: 14px; color: var(--ink-2); margin-top: 16px; line-height: 1.5; }
.ta-diff-strike {
  position: absolute; left: 16px; right: 16px; top: 50%;
  height: 2px; background: var(--ink-3); opacity: 0.5;
  transform: rotate(-2deg);
}
.ta-diff-arrow {
  display: flex; align-items: center;
  font-size: 40px;
  font-family: var(--font-display);
}
@media (max-width: 800px) {
  .ta-diff { grid-template-columns: 1fr; }
  .ta-diff-arrow { transform: rotate(90deg); justify-content: center; }
}

/* ---------- S5 inclusion ---------- */
.ta-check-list {
  margin-top: 40px;
  list-style: none;
  padding: 0;
  display: grid;
  gap: 14px;
}
.ta-check-item {
  display: flex;
  gap: 20px;
  align-items: flex-start;
  padding: 18px 22px;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: rgba(255,255,255,0.02);
  transition: border-color .2s;
}
.ta-check-item:hover { border-color: color-mix(in oklab, var(--ta-accent) 40%, var(--line)); }
.ta-check-mark {
  width: 28px; height: 28px;
  border-radius: 50%;
  border: 2px solid;
  display: flex; align-items: center; justify-content: center;
  font-size: 14px;
  font-weight: 700;
  flex-shrink: 0;
}
.ta-check-body { font-size: 17px; line-height: 1.5; color: var(--ink-1); }

/* ---------- S6 exclusion ---------- */
.ta-stop {
  display: inline-block;
  font-size: 14px;
  letter-spacing: 0.3em;
  background: linear-gradient(135deg, #ff5d73, #ff2659);
  color: #fff;
  padding: 10px 24px;
  border-radius: 4px;
  margin-bottom: 20px;
  font-weight: 700;
  box-shadow: 0 0 30px rgba(255,93,115,0.4);
  transform: rotate(-1.5deg);
}
.ta-xlist {
  list-style: none;
  padding: 0;
  margin: 40px 0 0;
  display: grid;
  gap: 14px;
}
.ta-xitem {
  display: flex;
  gap: 20px;
  align-items: flex-start;
  padding: 18px 22px;
  border: 1px solid rgba(255,93,115,0.22);
  border-radius: 12px;
  background: rgba(255,93,115,0.04);
}
.ta-xmark {
  width: 28px; height: 28px;
  border-radius: 50%;
  border: 2px solid #ff5d73;
  color: #ff5d73;
  display: flex; align-items: center; justify-content: center;
  font-size: 14px;
  font-weight: 700;
  flex-shrink: 0;
}
.ta-xbody { font-size: 16px; line-height: 1.5; color: var(--ink-1); }

.ta-empty {
  padding: 32px;
  border: 1px dashed var(--line-strong);
  border-radius: 12px;
  text-align: center;
  color: var(--ink-2);
  margin-top: 32px;
}

/* ---------- S7 endpoints ---------- */
.ta-quote {
  font-family: var(--font-display);
  font-style: italic;
  font-size: clamp(28px, 3.4vw, 44px);
  line-height: 1.25;
  color: var(--ink-0);
  margin: 32px 0;
  padding: 0;
  border: 0;
  quotes: none;
  max-width: 900px;
  position: relative;
}
.ta-quote::before {
  content: "";
  display: block;
  width: 60px; height: 4px;
  background: var(--ta-accent);
  margin-bottom: 24px;
  border-radius: 2px;
}
.ta-endpoints {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 20px;
  margin-top: 40px;
}
.ta-endpoint {
  padding: 24px;
  border: 1px solid var(--line);
  border-radius: 14px;
  background: rgba(255,255,255,0.02);
}
.ta-endpoint-kicker { font-size: 11px; letter-spacing: 0.25em; margin-bottom: 12px; }
.ta-endpoint-body { font-size: 16px; line-height: 1.45; color: var(--ink-0); }
.ta-endpoint-time { font-size: 12px; margin-top: 10px; }
.ta-endpoint-list { margin: 0; padding-left: 18px; color: var(--ink-1); font-size: 15px; line-height: 1.6; }
.ta-endpoint-list li { margin-bottom: 6px; }
@media (max-width: 800px) {
  .ta-endpoints { grid-template-columns: 1fr; }
}

/* ---------- S8 steps ---------- */
.ta-steps {
  list-style: none;
  padding: 0;
  margin: 40px 0 0;
  display: grid;
  gap: 18px;
}
.ta-step {
  display: flex;
  gap: 24px;
  align-items: flex-start;
  padding: 24px 28px;
  border: 1px solid var(--line);
  border-radius: 14px;
  background: linear-gradient(135deg, rgba(255,255,255,0.03), rgba(255,255,255,0.005));
}
.ta-step-num {
  width: 56px; height: 56px;
  border-radius: 50%;
  display: flex; align-items: center; justify-content: center;
  font-family: var(--font-display);
  font-size: 28px;
  color: #fff;
  font-weight: 600;
  flex-shrink: 0;
  box-shadow: 0 0 30px color-mix(in oklab, var(--ta-accent) 40%, transparent);
}
.ta-step-title {
  font-size: 13px;
  letter-spacing: 0.25em;
  color: var(--ta-accent);
  margin-bottom: 8px;
}
.ta-step-body { font-size: 17px; line-height: 1.5; color: var(--ink-1); }

.ta-phone {
  margin-top: 40px;
  padding: 32px;
  border: 2px solid var(--ta-accent);
  border-radius: 16px;
  text-align: center;
  background: linear-gradient(135deg, color-mix(in oklab, var(--ta-accent) 14%, transparent), transparent);
  box-shadow: 0 0 60px color-mix(in oklab, var(--ta-accent) 30%, transparent);
}
.ta-phone-kicker { font-size: 11px; letter-spacing: 0.3em; color: var(--ink-2); margin-bottom: 10px; }
.ta-phone-num {
  font-family: var(--font-display);
  font-size: clamp(40px, 6vw, 68px);
  line-height: 1;
  letter-spacing: -0.02em;
  color: var(--ink-0);
  text-decoration: none;
  display: inline-block;
}
.ta-phone-num:hover { color: var(--ta-accent); }

/* ---------- S9 ---------- */
.ta-brand {
  margin-top: 60px;
  font-size: 10px;
  letter-spacing: 0.35em;
  color: var(--ink-3);
}

/* ---------- PRINT: 9-page PDF layout ---------- */
/* =============================================================
   DEEP BRIEF (S10) — full NP education pulled from the library
   ============================================================= */
.ta-s10 {
  min-height: auto;
  padding: 96px 0 120px;
  background: linear-gradient(to bottom, transparent, rgba(5,4,10,0.9));
}
.tb-wrap { position: relative; }
.tb-head {
  max-width: 920px;
  margin-bottom: 56px;
}
.tb-eyebrow {
  font-size: 11px;
  letter-spacing: 0.3em;
  margin-bottom: 16px;
}
.tb-title {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: clamp(36px, 4.4vw, 56px);
  line-height: 1.05;
  letter-spacing: -0.02em;
  color: var(--ink-1);
  margin-bottom: 16px;
}
.tb-sub {
  color: var(--ink-2);
  font-size: 17px;
  line-height: 1.55;
  max-width: 680px;
}

/* masonry-ish 2-col grid */
.tb-grid {
  display: grid;
  grid-template-columns: repeat(6, 1fr);
  gap: 20px;
}
.tb-cell {
  grid-column: span 3;
  background: rgba(12,10,24,0.55);
  border: 1px solid var(--line);
  border-radius: 14px;
  padding: 26px 28px;
  position: relative;
  transition: border-color 0.3s ease, transform 0.3s ease;
}
.tb-cell:hover { border-color: color-mix(in srgb, var(--ta-accent) 35%, var(--line)); transform: translateY(-2px); }

/* featured cells span full width */
.tb-callout-cell, .tb-quote-cell, .tb-code-cell, .tb-split-cell { grid-column: span 6; }
.tb-list-cell { grid-column: span 6; }

.tb-cell-label {
  font-size: 10px;
  letter-spacing: 0.28em;
  text-transform: uppercase;
  margin-bottom: 14px;
  display: block;
}
.tb-prose {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: 18px;
  line-height: 1.55;
  color: var(--ink-1);
  text-wrap: pretty;
  white-space: pre-line;
}

/* ideal-patient callout */
.tb-callout-cell {
  background: linear-gradient(135deg, rgba(12,10,24,0.65), rgba(20,15,38,0.55));
}
.tb-callout-body {
  display: flex;
  gap: 18px;
  align-items: flex-start;
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: 22px;
  line-height: 1.45;
  color: var(--ink-1);
}
.tb-callout-quote {
  font-size: 80px;
  font-family: "Fraunces", serif;
  line-height: 0.7;
  margin-top: 22px;
}

/* eCW query code block */
.tb-code {
  font-family: "JetBrains Mono", ui-monospace, monospace;
  font-size: 13.5px;
  line-height: 1.65;
  color: var(--ink-1);
  background: rgba(0,0,0,0.35);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 18px 20px;
  margin: 0;
  white-space: pre-wrap;
}

/* risk/benefit split */
.tb-split { display: grid; grid-template-columns: 1fr 1fr; gap: 18px; }
.tb-split-half {
  padding: 18px 20px;
  border-radius: 10px;
  font-size: 15.5px;
  line-height: 1.55;
  color: var(--ink-1);
}
.tb-split-benefit { background: rgba(6, 224, 255, 0.06); border: 1px solid rgba(6, 224, 255, 0.18); }
.tb-split-risk    { background: rgba(255, 93, 115, 0.06); border: 1px solid rgba(255, 93, 115, 0.20); }
.tb-split-kicker {
  font-size: 10px;
  letter-spacing: 0.28em;
  margin-bottom: 8px;
}
.tb-split-risk-kicker { color: #ff5d73; }

/* provider talk track */
.tb-quote-cell {
  background: radial-gradient(ellipse at top left, color-mix(in srgb, var(--ta-accent) 8%, transparent), transparent 70%), rgba(12,10,24,0.55);
}
.tb-quote {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-style: italic;
  font-size: clamp(22px, 2.2vw, 30px);
  line-height: 1.35;
  color: var(--ink-1);
  margin: 0;
  quotes: "\201C" "\201D";
}
.tb-quote::before { content: open-quote; color: var(--ta-accent); margin-right: 4px; }
.tb-quote::after  { content: close-quote; color: var(--ta-accent); margin-left: 4px; }
.tb-quote-byline { font-size: 11px; letter-spacing: 0.28em; color: var(--ink-3); margin-top: 16px; }

/* sources */
.tb-list { margin: 0; padding: 0; list-style: none; }
.tb-list li {
  padding: 10px 0;
  border-top: 1px solid var(--line);
  font-size: 14.5px;
  color: var(--ink-2);
  display: flex;
  gap: 10px;
}
.tb-list li:first-child { border-top: 0; }
.tb-list li::before {
  content: "↳";
  color: var(--ta-accent);
  flex: 0 0 16px;
}

/* footer CTA */
.tb-footer {
  margin-top: 48px;
  padding: 24px 28px;
  border: 1px solid color-mix(in srgb, var(--ta-accent) 30%, var(--line));
  border-radius: 14px;
  background: color-mix(in srgb, var(--ta-accent) 5%, rgba(5,4,10,0.6));
  display: flex;
  gap: 24px;
  align-items: center;
  flex-wrap: wrap;
}
.tb-footer-kicker {
  font-size: 10px;
  letter-spacing: 0.3em;
  color: var(--ta-accent);
}
.tb-footer-body {
  font-size: 17px;
  color: var(--ink-1);
  flex: 1 1 420px;
}
.tb-footer-body a {
  color: var(--ta-accent);
  text-decoration: none;
  border-bottom: 1px solid currentColor;
  padding-bottom: 1px;
}

@media (max-width: 900px) {
  .tb-grid { grid-template-columns: 1fr; }
  .tb-cell,
  .tb-callout-cell, .tb-quote-cell, .tb-code-cell, .tb-split-cell, .tb-list-cell { grid-column: span 1; }
  .tb-split { grid-template-columns: 1fr; }
}

/* =============================================================
   STUDY EDUCATION PAGE — full rich page for every study
   ============================================================= */
.edu-page {
  --edu-accent: var(--accent);
  color: var(--ink-1);
  background: #05040a;
  padding-bottom: 120px;
}

/* ---- HERO ---- */
.edu-hero {
  position: relative;
  overflow: hidden;
  padding: 60px 0 80px;
  border-bottom: 1px solid var(--line);
}
.edu-hero-bg { position: absolute; inset: 0; z-index: 0; }
.edu-hero-glow { position: absolute; inset: 0; pointer-events: none; }
.edu-hero-inner {
  position: relative;
  z-index: 2;
  width: min(1280px, 92vw);
  margin: 0 auto;
  padding: 0 24px;
}
.edu-back {
  display: inline-block;
  font-size: 11px;
  letter-spacing: 0.3em;
  color: var(--ink-3);
  text-decoration: none;
  margin-bottom: 40px;
  transition: color 0.2s;
}
.edu-back:hover { color: var(--edu-accent); }

.edu-hero-badges {
  display: flex;
  gap: 10px;
  flex-wrap: wrap;
  margin-bottom: 36px;
}
.edu-chip, .edu-chip-ghost, .edu-chip-code {
  font-family: "JetBrains Mono", ui-monospace, monospace;
  font-size: 11px;
  letter-spacing: 0.2em;
  padding: 7px 14px;
  border-radius: 999px;
  border: 1px solid var(--line);
  background: rgba(12,10,24,0.5);
  text-decoration: none;
  color: var(--ink-2);
}
.edu-chip { padding: 7px 14px 7px 10px; }
.edu-chip::before { content: "●"; margin-right: 6px; }
.edu-chip-ghost { color: var(--ink-3); }
.edu-chip-code { font-weight: 600; }

.edu-hero-title {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: clamp(56px, 9vw, 128px);
  line-height: 0.95;
  letter-spacing: -0.035em;
  margin: 0 0 20px;
}
.edu-hero-drug { display: block; color: var(--ink-1); }
.edu-hero-rest { display: block; color: var(--ink-2); font-size: 0.6em; font-style: italic; font-weight: 300; margin-top: 10px; }
.edu-hero-sub {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: clamp(20px, 2.1vw, 28px);
  line-height: 1.35;
  color: var(--ink-1);
  max-width: 820px;
  margin: 0 0 24px;
  text-wrap: pretty;
}
.edu-hero-meta { font-size: 12px; color: var(--ink-3); margin-bottom: 32px; }
.edu-meta-dot { margin: 0 10px; opacity: 0.5; }

.edu-hook {
  margin: 28px 0 40px;
  padding: 24px 28px;
  border-left: 3px solid var(--edu-accent);
  border-radius: 0 10px 10px 0;
  background: linear-gradient(90deg, color-mix(in srgb, var(--edu-accent) 8%, transparent), transparent);
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-style: italic;
  font-size: clamp(20px, 2.1vw, 26px);
  line-height: 1.4;
  color: var(--ink-1);
  max-width: 920px;
  position: relative;
}
.edu-hook-glyph {
  font-size: 48px;
  font-family: "Fraunces", serif;
  line-height: 0;
  position: absolute;
  top: 26px; left: -6px;
}

.edu-hero-actions { display: flex; gap: 12px; flex-wrap: wrap; margin-bottom: 56px; }

.edu-glance {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 1px;
  background: var(--line);
  border: 1px solid var(--line);
  border-radius: 14px;
  overflow: hidden;
}
.edu-glance-cell {
  background: rgba(12,10,24,0.65);
  padding: 20px 24px;
  display: flex;
  flex-direction: column;
  gap: 6px;
}
.edu-glance-n {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: clamp(28px, 3.2vw, 44px);
  line-height: 1;
  letter-spacing: -0.02em;
}
.edu-glance-label { font-size: 10px; letter-spacing: 0.28em; color: var(--ink-3); text-transform: uppercase; }

/* ---- BODY (TOC + Main) ---- */
.edu-body {
  width: min(1280px, 92vw);
  margin: 72px auto 0;
  padding: 0 24px;
  display: grid;
  grid-template-columns: 260px 1fr;
  gap: 64px;
}

.edu-aside { position: relative; }
.edu-toc {
  position: sticky;
  top: 96px;
  max-height: calc(100vh - 120px);
  overflow-y: auto;
  padding-right: 12px;
}
.edu-toc-kicker { font-size: 10px; letter-spacing: 0.3em; color: var(--ink-3); margin-bottom: 18px; }
.edu-toc-list { list-style: none; margin: 0; padding: 0; }
.edu-toc-item { border-left: 1px solid var(--line); }
.edu-toc-link {
  width: 100%;
  display: flex;
  gap: 14px;
  padding: 10px 0 10px 18px;
  background: transparent;
  border: 0;
  color: var(--ink-3);
  cursor: pointer;
  text-align: left;
  font-size: 14px;
  line-height: 1.4;
  transition: color 0.2s ease;
  position: relative;
}
.edu-toc-link::before {
  content: "";
  position: absolute;
  left: -1px; top: 0; bottom: 0;
  width: 2px;
  background: transparent;
  transition: background 0.2s;
}
.edu-toc-item.active .edu-toc-link,
.edu-toc-link:hover { color: var(--ink-1); }
.edu-toc-item.active .edu-toc-link::before { background: var(--edu-accent); }
.edu-toc-num { font-size: 10px; letter-spacing: 0.15em; color: var(--ink-3); padding-top: 2px; min-width: 22px; }
.edu-toc-item.active .edu-toc-num { color: var(--edu-accent); }

.edu-aside-cta {
  margin-top: 32px;
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: rgba(12,10,24,0.5);
}
.edu-cta-kicker { font-size: 10px; letter-spacing: 0.3em; color: var(--ink-3); margin-bottom: 8px; }
.edu-cta-phone {
  display: block;
  font-family: "Fraunces", serif;
  font-weight: 400;
  font-size: 22px;
  color: var(--ink-1);
  text-decoration: none;
  margin-bottom: 6px;
}
.edu-cta-phone:hover { color: var(--edu-accent); }
.edu-cta-code { font-size: 11px; letter-spacing: 0.15em; color: var(--ink-3); }
.edu-cta-code strong { color: var(--edu-accent); letter-spacing: 0.2em; }

/* ---- Main content ---- */
.edu-main { min-width: 0; }
.edu-section {
  padding: 56px 0;
  border-bottom: 1px solid var(--line);
  scroll-margin-top: 80px;
}
.edu-section:last-child { border-bottom: 0; }

.edu-sec-head {
  display: flex;
  gap: 24px;
  align-items: flex-start;
  margin-bottom: 28px;
}
.edu-sec-num {
  font-size: 13px;
  letter-spacing: 0.2em;
  padding-top: 10px;
  min-width: 36px;
}
.edu-sec-kicker { font-size: 11px; letter-spacing: 0.3em; margin-bottom: 6px; }
.edu-sec-title {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: clamp(32px, 3.8vw, 48px);
  line-height: 1.05;
  letter-spacing: -0.02em;
  margin: 0;
  color: var(--ink-1);
}
.edu-sec-body { padding-left: 60px; }

.edu-prose {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: clamp(18px, 1.6vw, 21px);
  line-height: 1.55;
  color: var(--ink-1);
  max-width: 760px;
  text-wrap: pretty;
  white-space: pre-line;
}

.edu-lede {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: 20px;
  line-height: 1.5;
  color: var(--ink-1);
  max-width: 760px;
  margin: 0 0 24px;
}

.edu-list-kicker {
  font-size: 10px;
  letter-spacing: 0.3em;
  color: var(--ink-3);
  margin-bottom: 12px;
}

/* MOA receptor pills */
.edu-moa-text { font-family: "Fraunces", serif; font-weight: 300; font-size: 21px; line-height: 1.6; color: var(--ink-1); max-width: 820px; text-wrap: pretty; }
.edu-receptor {
  display: inline-block;
  font-family: "JetBrains Mono", ui-monospace, monospace;
  font-size: 0.78em;
  font-weight: 600;
  padding: 1px 8px;
  border: 1px solid var(--edu-accent);
  border-radius: 4px;
  margin: 0 2px;
  letter-spacing: 0.04em;
  background: color-mix(in srgb, var(--edu-accent) 8%, transparent);
  vertical-align: 2px;
}

/* Registry strip under study design */
.edu-reg-strip {
  display: flex;
  gap: 14px;
  flex-wrap: wrap;
  margin-top: 28px;
  padding: 14px 18px;
  border: 1px dashed var(--line);
  border-radius: 10px;
}
.edu-reg-strip .mono { font-size: 11px; letter-spacing: 0.2em; color: var(--ink-2); }

/* Criteria lists */
.edu-crit { list-style: none; margin: 0 0 8px; padding: 0; max-width: 860px; }
.edu-crit-item {
  display: flex;
  gap: 16px;
  padding: 14px 0;
  border-top: 1px solid var(--line);
  font-size: 16px;
  line-height: 1.5;
  color: var(--ink-1);
}
.edu-crit-item:first-child { border-top: 0; }
.edu-crit-mark {
  flex: 0 0 24px;
  width: 24px;
  height: 24px;
  border: 1.5px solid;
  border-radius: 50%;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  font-size: 13px;
  font-weight: 600;
  margin-top: 1px;
}
.edu-crit-ex .edu-crit-mark { color: #ff5d73; border-color: #ff5d73; }

.edu-foot { font-size: 13px; color: var(--ink-3); margin-top: 20px; }
.edu-empty { font-size: 13px; padding: 16px; border: 1px dashed var(--line); border-radius: 10px; color: var(--ink-3); }

/* Ideal patient */
.edu-ideal-card {
  display: flex;
  gap: 22px;
  padding: 28px 32px;
  border: 1px solid var(--edu-accent);
  border-radius: 14px;
  background: color-mix(in srgb, var(--edu-accent) 6%, rgba(12,10,24,0.55));
  max-width: 900px;
}
.edu-ideal-glyph { font-size: 32px; line-height: 1; padding-top: 4px; }
.edu-ideal-body {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: 24px;
  line-height: 1.45;
  color: var(--ink-1);
}

/* eCW code block */
.edu-code {
  font-family: "JetBrains Mono", ui-monospace, monospace;
  font-size: 13.5px;
  line-height: 1.7;
  color: var(--ink-1);
  background: rgba(0,0,0,0.45);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 20px 22px;
  margin: 0;
  white-space: pre-wrap;
  max-width: 860px;
}

/* Risk / benefit split */
.edu-split { display: grid; grid-template-columns: 1fr 1fr; gap: 18px; max-width: 920px; }
.edu-split-half {
  padding: 22px 24px;
  border-radius: 12px;
  font-size: 16px;
  line-height: 1.55;
  color: var(--ink-1);
}
.edu-split-benefit { background: rgba(6, 224, 255, 0.06); border: 1px solid rgba(6, 224, 255, 0.22); }
.edu-split-risk    { background: rgba(255, 93, 115, 0.06); border: 1px solid rgba(255, 93, 115, 0.22); }
.edu-split-kicker { font-size: 10px; letter-spacing: 0.3em; margin-bottom: 10px; }
.edu-split-risk-kicker { color: #ff5d73; }

/* Talk track */
.edu-talk {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-style: italic;
  font-size: clamp(24px, 3vw, 34px);
  line-height: 1.35;
  color: var(--ink-1);
  margin: 0;
  max-width: 900px;
  position: relative;
}
.edu-talk-glyph { font-size: 48px; line-height: 0; }
.edu-talk-glyph-end { display: none; }
.edu-talk-byline { font-size: 11px; letter-spacing: 0.28em; color: var(--ink-3); margin-top: 16px; }

/* Endpoints */
.edu-reg-summary {
  font-size: 15px;
  color: var(--ink-2);
  line-height: 1.55;
  margin-bottom: 24px;
  max-width: 820px;
}
.edu-endpoint {
  padding: 18px 20px;
  border: 1px solid var(--line);
  border-radius: 10px;
  margin-bottom: 14px;
  max-width: 860px;
}
.edu-endpoint-kicker { font-size: 10px; letter-spacing: 0.3em; margin-bottom: 8px; }
.edu-endpoint-body { font-size: 16px; line-height: 1.5; color: var(--ink-1); }
.edu-endpoint-time { font-size: 11px; letter-spacing: 0.15em; margin-top: 6px; }
.edu-endpoint-list { margin: 8px 0 0; padding-left: 20px; color: var(--ink-2); font-size: 14.5px; line-height: 1.6; }

/* Steps */
.edu-steps { list-style: none; margin: 0 0 40px; padding: 0; max-width: 860px; }
.edu-step {
  display: flex;
  gap: 20px;
  padding: 18px 0;
  border-top: 1px solid var(--line);
}
.edu-step:first-child { border-top: 0; }
.edu-step-num {
  flex: 0 0 48px;
  width: 48px;
  height: 48px;
  border-radius: 50%;
  color: #0a0812;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  font-family: "Fraunces", serif;
  font-weight: 400;
  font-size: 22px;
}
.edu-step-title { font-size: 11px; letter-spacing: 0.3em; margin-bottom: 6px; color: var(--edu-accent); }
.edu-step-body { font-size: 16px; line-height: 1.5; color: var(--ink-1); }

.edu-refer-card {
  display: flex;
  gap: 32px;
  flex-wrap: wrap;
  align-items: center;
  padding: 24px 28px;
  border: 1px solid;
  border-radius: 14px;
  background: color-mix(in srgb, var(--edu-accent) 5%, rgba(12,10,24,0.55));
  max-width: 860px;
}
.edu-refer-kicker { font-size: 10px; letter-spacing: 0.3em; color: var(--ink-3); margin-bottom: 6px; }
.edu-refer-phone {
  font-family: "Fraunces", serif;
  font-weight: 300;
  font-size: 36px;
  color: var(--ink-1);
  text-decoration: none;
}
.edu-refer-phone:hover { color: var(--edu-accent); }
.edu-refer-codeval {
  font-family: "JetBrains Mono", ui-monospace, monospace;
  font-size: 18px;
  font-weight: 600;
  letter-spacing: 0.15em;
  color: var(--edu-accent);
}

/* Sources */
.edu-sources { list-style: none; margin: 0; padding: 0; max-width: 860px; }
.edu-sources li {
  padding: 12px 0;
  border-top: 1px solid var(--line);
  font-size: 14.5px;
  color: var(--ink-2);
  display: flex;
  gap: 10px;
}
.edu-sources li:first-child { border-top: 0; }
.edu-sources li::before {
  content: "↳";
  color: var(--edu-accent);
  flex: 0 0 16px;
}
.edu-sources a { color: var(--edu-accent); text-decoration: none; border-bottom: 1px dashed currentColor; }

/* Sticky bottom CTA */
.edu-stickycta {
  position: fixed;
  bottom: 16px;
  left: 50%;
  transform: translateX(-50%);
  width: min(1280px, 92vw);
  z-index: 80;
  pointer-events: none;
}
.edu-stickycta-inner {
  pointer-events: auto;
  display: flex;
  gap: 20px;
  align-items: center;
  justify-content: space-between;
  padding: 14px 20px;
  background: rgba(5,4,10,0.92);
  border: 1px solid var(--line);
  border-radius: 14px;
  backdrop-filter: blur(10px);
  box-shadow: 0 20px 60px -20px rgba(0,0,0,0.6);
}
.edu-stickycta-eyebrow { font-size: 10px; letter-spacing: 0.28em; margin-bottom: 4px; }
.edu-stickycta-drug { font-size: 14px; color: var(--ink-1); font-weight: 500; }
.edu-stickycta-actions { display: flex; gap: 10px; align-items: center; flex-wrap: wrap; }
.edu-stickycta-code {
  font-size: 10px;
  letter-spacing: 0.2em;
  padding: 6px 10px;
  border: 1px solid;
  border-radius: 6px;
}

@media (max-width: 900px) {
  .edu-body { grid-template-columns: 1fr; gap: 48px; }
  .edu-toc { position: relative; top: auto; max-height: none; }
  .edu-sec-body { padding-left: 0; }
  .edu-split { grid-template-columns: 1fr; }
  .edu-glance { grid-template-columns: repeat(2, 1fr); }
  .edu-stickycta-inner { flex-direction: column; align-items: stretch; }
  .edu-stickycta-actions { justify-content: flex-end; }
}

@media print {
  @page {
    size: letter landscape;
    margin: 0;
  }
  body {
    background: #05040a !important;
    -webkit-print-color-adjust: exact !important;
    print-color-adjust: exact !important;
  }
  /* hide all chrome */
  nav, .nav, .footer, .tweaks-panel, .tweaks-toggle, .ta-rail,
  .ta-back, .ta-actions, #scrollProgress, .scroll-progress,
  .grain, .nav-inner, .nav-overlay { display: none !important; }
  main { padding-top: 0 !important; }
  /* one slide per page */
  .trial-alert { display: block; }
  .ta-section {
    page-break-after: always;
    break-after: page;
    min-height: 8.2in;
    height: 8.2in;
    padding: 48px 0 !important;
    border: 0 !important;
    display: flex !important;
    align-items: center !important;
  }
  .ta-section:last-of-type {
    page-break-after: auto;
    break-after: auto;
  }
  .ta-pageno { display: block; }
  .ta-bg-glow { opacity: 0.6 !important; }
  /* shrink hero type for print */
  .ta-hero { font-size: 120px !important; }
  .ta-big2 { font-size: 64px !important; }
  .ta-h2.ta-big { font-size: 54px !important; }
  .ta-h2 { font-size: 44px !important; }
  .ta-quote { font-size: 30px !important; }
  .ta-phone-num { font-size: 48px !important; }
  /* keep neural bg printable */
  canvas, svg { filter: none !important; }
}